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Using two separate drugs to shed pounds can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight reduction and the people that go through it you should err on the side of caution and permit the FDA do its job and demand some study be done in order that the public is aware of the side effects and perils associated with the medications before we bring them. Keep in mind that drug companies come in business to earn money and that they would say anything to keep people on his or her medications. Researchers discovered that participants using this drug for a year, dropped excess weight within four weeks and have kept the extra weight off during the entire 56 weeks in the study. Contrave is a combination in the drugs naltrexone and bupropion, which usually reflect a fresh trend of weight-loss drugs which might be made up of more than one active ingredient, which may make them far better and safer. Combo-pilling is the newest fad or also the newest ahead under scrutiny and for that reason it is just more publicly known lately, comb-pilling to lose weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular may be the fact that since right now there aren't long term prescription slimming capsules that have been approved by the FDA besides orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA. Seizures really are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug may also raise hypertension and heartbeat, and mustn't be used in people who have a history of cardiac event or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy with the drug. The FDA also warned that Contrave can raise hypertension and heartrate and must not be used in patients with uncontrolled high blood pressure, and also by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients for the increased chance of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for smoking cessation. 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